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KMID : 0617219970080010001
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Duksung Bulletin Phamaceutical Sciences
1997 Volume.8 No. 1 p.1 ~ p.6
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Synthesis of 1,2-Benzothiazine-3-carboxamide derivatives and Analgesic activities
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Abstract
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Seven new 7-H(or bromo)-4-hydroxy-2H(or methyl)-N-(5-aralkyl-3-aminohydantoinyl) -1,2-benzothiazine-3-carboxamide-1,1-dioxide derivatives were synthesized through the condensation of 7-H(or bromo)-4-hydroxy-2H(or methyl)-1,2-benzothiazine-3-carboxylic acid methyl ester 1,1-dioxides with 5-substituted-3-aminohydantoins. The analgesic activities of the synthesized compounds were investigated by Randall-Selitto assay. Most compounds exhibited lower activities but compound 6 and 7 showed higher analgesic activities than piroxicam.
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